Stacked Damage-Repair Under Chronic Infection

Linked theories: Pathogen Control (Lidsky), SENS Damage Repair (de Grey)

Hypothesis

Stacked repairs that extend lifespan increase infection persistence/transmission proxies unless anti-pathogen interventions co-apply.

Design

• Model: Aged C57BL/6J, chronic low-virulence infection.
• Arms (N=50/arm): Vehicle; Best single repair; Stacked repairs; Anti-pathogen; Stacked+Anti-pathogen.
• Repairs: e.g., senolytics (D+Q), crosslink breaker candidate, aggregate clearance; calibrate doses via pilot.

Endpoints

• Hazard, maximum lifespan, infection burden/transmission proxies, frailty, pathology panel.

Time & Cost (est.)

• 18–30 months; $700k–$1.5M.

Discriminator

• PC: Stacked repairs alone show infection penalties or limited hazard benefit vs combined arm.
• SENS: Stacked repairs extend lifespan without infection penalties under challenge.